Industry-Ready Course in Organic Synthesis

Industry-Ready Course in Organic Synthesis

Offered by Global South Varsity

Module 1: Industrial Lab Safety, Setup, and Monitoring (Week 1)

• Lab Safety Protocols: Proper use of personal protective equipment (PPE), handling hazardous/volatile chemicals, waste management, and executing critical emergency procedures.
• Reaction Setup: Selecting and assembling precision glassware, techniques for handling moisture-sensitive reagents, and establishing inert atmospheres.
• Reaction Monitoring:Optimising Thin Layer Chromatography (TLC) plates, mastering solvent system selection, understanding co-spotting, and utilizing UV lamps and chemical stains for visualization.

Module 2: Reaction Execution and Optimization (Week 2)

• Standard Reaction Conditions: Running reactions under precise conditions, including Room Temperature (RT), cryogenic settings (cooling baths), and continuous Reflux setups.
• Microwave-Assisted Synthesis: Principles of microwave heating, specialized vessel setup, safety boundaries, and programming reaction parameters (time, pressure, temperature).
• Optimization & Workup: Systematic screening of reaction conditions to improve chemical yield, followed by washing protocols, and rotary evaporation.

Module 3: Purification Techniques (Week 3)

• Manual Column Chromatography: Stationary phase selection (Silica/Alumina gel matrix), wet slurry packing vs. dry packing techniques, sample loading (wet/dry), and effective fraction collection.
• Flash Column Chromatography: Introduction to modern automated flash systems, choosing optimal pre-packed cartridges, and translating TLC data into gradient elution methods.
• HPLC Preparation: Fundamentals of High-Performance Liquid Chromatography (Normal vs. Reverse Phase), degassed mobile phase preparation, and general column maintenance.

Module 4: Characterization and Analysis (Week 4)

• NMR Spectroscopy: Proper analytical sample preparation (deuterated solvent selection and filtering) alongside structured interpretation of ¹H and ¹³C NMR spectra for structural verification.
• Mass Spectrometry (MS): Core principles of key ionization methods (ESI/APCI) coupled with liquid chromatography (LC-MS) and identifying molecular ion peaks to confirm targeted mass.
• Data Compilation & Reporting: Integrating TLC, HPLC, NMR, and Mass Spectrometry data to confirm structural identity and establish final compound purity.

⚠️ Important Laboratory Note

To maximize the outcome of this intensive hands-on course, strict adherence to professional laboratory standards is required from day one. Please keep the following requirements in mind:

• Mandatory Gear: Participants must wear a standard full-sleeve cotton laboratory coat and covered footwear (shoes) at all times in the wet-lab.
• Laboratory Notebook: Bringing a dedicated hardbound lab notebook for real-time tracking of reaction parameters, TLC coordinates, and purification data is strictly required.
• Calculators & Laptops: A scientific calculator is recommended for quick stoichiometry/molarity math. Laptops are encouraged during Week 4 to practice digital spectral processing and interpretation.

Summer 2026 Batch

📅 Starting July 03, 2026 onwards
⏰ Duration: 1 Month (Intensive)

Course Enrollment Process:

Enrollment is only considered complete once the payment has been successfully made and the payment confirmation screenshot is uploaded to your application.

• Fill in all required fields accurately on the enrollment form.
• All participants are requested to bring one copy each of their Institutional ID and Personal ID.